Clinical Studies
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Lung Tumor Fluid Dynamics Study
OpenCurrent chemotherapy treatments involve a direct injection into the tumor. We would like to use surgically removed lung tissue to better understand how drugs behave when they are injected into lung tumors in dogs, as well as humans, with lung tumors.
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Methylnaltrexone (MNTX) Clinical Study
OpenThis study seeks to define the rate at which methylnaltrexone (MNTX) is metabolized in dogs following intravenous administration. Postoperative regurgitation is a common side effect of general anesthesia. The opioid-inhibiting effects of MNTX block the risk of opioid-related complications, without reducing pain control and pain management.
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Evaluation of Liver Protectants for Xylitol Toxicity in Dogs
OpenXylitol is an artificial sweetener commonly found in sugar-free gum. Although safe for humans, xylitol is highly toxic to dogs. This study will compare the liver protective capacity of two veterinary liver protectant products in dogs suffering from xylitol toxicity.
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Embolization of the Splenic Artery for Thrombocytopenia (eSPAT)
ClosedImmune-mediated thrombocytopenia (ITP) is a disorder characterized by severely low platelets due to attack by white blood cells. This is often associated with bruising and occasionally severe bleeding episodes.
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Evaluating the Tolerability of Combination of Verdinexor and Doxorubicin in Dogs with Cancer
ClosedVerdinexor is a chemotherapy drug that has been conditionally approved by the FDA for the treatment of canine lymphoma. Verdinexor is a selective inhibitor of nuclear export (SINE) compound, and this family of drug has demonstrated encouraging results in preclinical studies when combined with other chemotherapeutic drugs.
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Metabolomics Trial to Evaluate for Systemic Consequences of Intestinal Dysbiosis
ClosedThe intestinal microbiota are highly functional, with a combined genome (termed the microbiome) that is approximately 130-160 times larger than the human or canine genome. The microbiome is a highly functional organ and produces approximately 1,000 different metabolites, many of which have systemic effects in the dog.
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ORBITS Clinical Study
OpenDespite years of active research in the field, high mortality rates associated with sepsis have remained unchanged over the last three decades; we aim to change this!
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Minimally Invasive Metastasectomy in Canines (MIMIC)
OpenFollowing removal of the primary tumor and adjuvant chemotherapy, the development of lung metastasis is the most common cause of mortality in dogs with osteosarcoma. A distinctive feature of lung metastases of osteosarcoma in human patients is the surprising benefit that can result from surgical resection of the lung nodules. The use of surgery to
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K9 Tumor And Blood Sampling for Osteosarcoma and Oral Melanoma (KABOOM)
OpenNaturally occurring cancers in dogs have been as used as models for human cancers for many reasons; however, the genomic profiles of many of these cancers are still incompletely understood. Further definition of these genomic landscapes will allow for improved development of novel diagnostics and therapeutics to diagnose and treat these cancers. The objective of this
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Tolerability of Oral Paclitaxel in Cancer-Bearing Dogs
ClosedResearch Type Ethos Discovery De Novo Study Description Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second
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Ethos Precision Medicine Umbrella Study for Hemangiosarcoma (Ethos-PUSH)
OpenIs your dog undergoing surgery for a ruptured splenic tumor? Ethos Discovery would love to have you and your dog participate in our clinical trial! We are evaluating drugs for the treatment of HSA with the goal of curing this aggressive cancer.
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DIABETIC Cat Study
ClosedWe are investigating a new diet that may potentially induce insulin remission in cats with newly diagnosed diabetes.
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